Drug interactions
Olodaterol inhaled + Posaconazole
Severity: Moderate
Olodaterol inhaled and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can prolong the QT interval and olodaterol, a long-acting beta2 agonist, can affect cardiac repolarization at high exposure. Combined use may add to the risk of arrhythmia in susceptible patients, though inhaled olodaterol exposure is low.
What this interaction means in plain words
Olodaterol inhaled and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation and beta2-mediated cardiovascular effects, with possible minor CYP3A4/P-gp-related exposure increase.
What to do
Check baseline ECG and correct potassium and magnesium in patients with cardiac risk factors; monitor for palpitations or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Olodaterol inhaled with Posaconazole?
MediHelp rates the interaction as moderate. Olodaterol inhaled and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can prolong the QT interval and olodaterol, a long-acting beta2 agonist, can affect cardiac repolarization at high exposure. Combined use may add to the risk of arrhythmia in susceptible patients, though inhaled olodaterol exposure is low.
How serious is the interaction between Olodaterol inhaled and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium in patients with cardiac risk factors; monitor for palpitations or arrhythmia.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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