Drug interactions
Olopatadine intranasal + Prochlorperazine
Severity: Moderate
Olopatadine intranasal and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and prochlorperazine is also sedating. Together they may add to drowsiness and psychomotor impairment.
What this interaction means in plain words
Olopatadine intranasal and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistaminergic and phenothiazine sedative effects.
What to do
Counsel patients to avoid driving or operating machinery until the response is known. Consider a lower dose or a non-sedating alternative if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Olopatadine intranasal with Prochlorperazine?
MediHelp rates the interaction as moderate. Olopatadine intranasal and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and prochlorperazine is also sedating. Together they may add to drowsiness and psychomotor impairment.
How serious is the interaction between Olopatadine intranasal and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or operating machinery until the response is known. Consider a lower dose or a non-sedating alternative if drowsiness is troublesome.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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