Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Posaconazole
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor, and paritaprevir and ritonavir are CYP3A substrates, so exposure to the antiviral regimen may rise. Higher paritaprevir levels may increase the risk of hepatic and other adverse effects, and ritonavir may in turn raise posaconazole exposure.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of paritaprevir and ritonavir, and ritonavir inhibits CYP3A4 metabolism of posaconazole.
What to do
Avoid the combination where an alternative antifungal or HCV regimen exists. If it is unavoidable, monitor liver function and for adverse effects of both agents.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Posaconazole?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a strong CYP3A4 inhibitor, and paritaprevir and ritonavir are CYP3A substrates, so exposure to the antiviral regimen may rise. Higher paritaprevir levels may increase the risk of hepatic and other adverse effects, and ritonavir may in turn raise posaconazole exposure.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antifungal or HCV regimen exists. If it is unavoidable, monitor liver function and for adverse effects of both agents.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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