Drug interactions
Ombitasvir / paritaprevir / ritonavir + Posaconazole
Severity: Major
Ombitasvir / paritaprevir / ritonavir and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and may raise paritaprevir and ritonavir exposure. Ritonavir also inhibits CYP3A4, raising posaconazole-related uncertainty. Both groups have QT or hepatic safety concerns, so toxicity may increase.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Posaconazole inhibits CYP3A4 and P-gp, which may increase paritaprevir and ritonavir concentrations.
What to do
Avoid if possible and choose an alternative antifungal or HCV regimen. If used, monitor liver enzymes and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir with Posaconazole?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole inhibits CYP3A4 and may raise paritaprevir and ritonavir exposure. Ritonavir also inhibits CYP3A4, raising posaconazole-related uncertainty. Both groups have QT or hepatic safety concerns, so toxicity may increase.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative antifungal or HCV regimen. If used, monitor liver enzymes and ECG.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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