Drug interactions
Omeprazole + Pexidartinib
Severity: Major
Omeprazole and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib absorption is reduced when gastric pH rises, and PPIs lower its exposure. This may reduce its efficacy.
What this interaction means in plain words
Omeprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Omeprazole belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Increased gastric pH reduces pexidartinib solubility and absorption.
What to do
Avoid PPIs. If needed, use an antacid or H2 antagonist, dosing pexidartinib 2 hours before or after the antacid, or at least 2 hours before or 10 hours after the H2 antagonist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Omeprazole with Pexidartinib?
MediHelp rates the interaction as major. Omeprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib absorption is reduced when gastric pH rises, and PPIs lower its exposure. This may reduce its efficacy.
How serious is the interaction between Omeprazole and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs. If needed, use an antacid or H2 antagonist, dosing pexidartinib 2 hours before or after the antacid, or at least 2 hours before or 10 hours after the H2 antagonist.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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