Drug interactions
Omeprazole + Riociguat
Severity: Moderate
Omeprazole and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat solubility falls at higher gastric pH, so omeprazole may reduce its absorption. Lower exposure could reduce efficacy in pulmonary hypertension.
What this interaction means in plain words
Omeprazole and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Riociguat belongs to Cardiovascular.
Why it happens
Elevated gastric pH reduces dissolution and absorption of riociguat.
What to do
Monitor clinical response and blood pressure, and adjust riociguat dose if needed when starting or stopping the PPI.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Omeprazole with Riociguat?
MediHelp rates the interaction as moderate. Omeprazole and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat solubility falls at higher gastric pH, so omeprazole may reduce its absorption. Lower exposure could reduce efficacy in pulmonary hypertension.
How serious is the interaction between Omeprazole and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood pressure, and adjust riociguat dose if needed when starting or stopping the PPI.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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