Drug interactions
Omeprazole + Ritonavir
Severity: Minor
Omeprazole and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP3A4 and may raise omeprazole concentrations. Omeprazole is generally well tolerated, so the increase is usually modest, but exposure may rise with prolonged use.
What this interaction means in plain words
Omeprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4, a secondary pathway of omeprazole metabolism.
What to do
No routine adjustment is needed, but consider dose review if high omeprazole doses are used for long periods.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Omeprazole with Ritonavir?
MediHelp rates the interaction as minor. Omeprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir inhibits CYP3A4 and may raise omeprazole concentrations. Omeprazole is generally well tolerated, so the increase is usually modest, but exposure may rise with prolonged use.
How serious is the interaction between Omeprazole and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed, but consider dose review if high omeprazole doses are used for long periods.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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