Drug interactions
Omeprazole + Sparsentan
Severity: Moderate
Omeprazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole may lower sparsentan exposure, potentially reducing its antiproteinuric benefit in IgA nephropathy. The clinical impact is mainly loss of efficacy.
What this interaction means in plain words
Omeprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Higher gastric pH from the PPI is thought to reduce the solubility and absorption of sparsentan.
What to do
Review the need for the PPI and use the lowest effective acid suppression if it is required. Monitor proteinuria and blood pressure response to sparsentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Omeprazole with Sparsentan?
MediHelp rates the interaction as moderate. Omeprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole may lower sparsentan exposure, potentially reducing its antiproteinuric benefit in IgA nephropathy. The clinical impact is mainly loss of efficacy.
How serious is the interaction between Omeprazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for the PPI and use the lowest effective acid suppression if it is required. Monitor proteinuria and blood pressure response to sparsentan.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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