Drug interactions
Omeprazole + Voxelotor
Severity: Minor
Omeprazole and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can raise exposure to sensitive CYP3A4 substrates. Omeprazole is mainly cleared by CYP2C19 and has a wide safety margin, so a clinically important effect is unlikely.
What this interaction means in plain words
Omeprazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, a minor elimination pathway of omeprazole.
What to do
No dose adjustment is usually required. Monitor for omeprazole adverse effects if high doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Omeprazole with Voxelotor?
MediHelp rates the interaction as minor. Omeprazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor can raise exposure to sensitive CYP3A4 substrates. Omeprazole is mainly cleared by CYP2C19 and has a wide safety margin, so a clinically important effect is unlikely.
How serious is the interaction between Omeprazole and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Monitor for omeprazole adverse effects if high doses are used.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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