Drug interactions
Ondansetron + Pasireotide
Severity: Moderate
Ondansetron and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can cause bradycardia and QT prolongation, and ondansetron also prolongs the QT interval. Combined use increases arrhythmia risk.
What this interaction means in plain words
Ondansetron and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Pasireotide belongs to Endocrine.
Why it happens
Additive QT prolongation and bradycardic effects.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor ECG during coadministration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Ondansetron with Pasireotide?
MediHelp rates the interaction as moderate. Ondansetron and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can cause bradycardia and QT prolongation, and ondansetron also prolongs the QT interval. Combined use increases arrhythmia risk.
How serious is the interaction between Ondansetron and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor ECG during coadministration.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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