Drug interactions
Ondansetron + Pazopanib
Severity: Major
Ondansetron and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and pazopanib labeling also warns of torsades de pointes. Concurrent use may add to the arrhythmia risk, especially with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Ondansetron and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ondansetron belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Additive inhibition of cardiac repolarizing potassium currents leading to QT prolongation.
What to do
Obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium. Consider a non-QT-prolonging antiemetic if the patient has other risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Ondansetron with Pazopanib?
MediHelp rates the interaction as major. Ondansetron and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and pazopanib labeling also warns of torsades de pointes. Concurrent use may add to the arrhythmia risk, especially with electrolyte disturbances or cardiac disease.
How serious is the interaction between Ondansetron and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium. Consider a non-QT-prolonging antiemetic if the patient has other risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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