Drug interactions
Ondansetron + Rifabutin
Severity: Minor
Ondansetron and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower ondansetron concentrations. The effect is expected to be small, though antiemetic response could be reduced.
What this interaction means in plain words
Ondansetron and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induction of CYP3A4 increases ondansetron clearance.
What to do
No dose adjustment is needed; monitor for breakthrough nausea and vomiting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Ondansetron with Rifabutin?
MediHelp rates the interaction as minor. Ondansetron and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces CYP3A4 and may lower ondansetron concentrations. The effect is expected to be small, though antiemetic response could be reduced.
How serious is the interaction between Ondansetron and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for breakthrough nausea and vomiting.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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