Drug interactions
Ondansetron + Selegiline
Severity: Moderate
Ondansetron and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor, and ondansetron has been associated with serotonin syndrome when combined with serotonergic drugs. The risk is probably low at oral doses of selegiline used in Parkinson disease but may be higher with higher doses or the transdermal form.
What this interaction means in plain words
Ondansetron and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Selegiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect; MAO inhibition increases serotonin availability.
What to do
Monitor for signs of serotonin toxicity when ondansetron is given with selegiline. Consider a non-serotonergic antiemetic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Ondansetron with Selegiline?
MediHelp rates the interaction as moderate. Ondansetron and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO inhibitor, and ondansetron has been associated with serotonin syndrome when combined with serotonergic drugs. The risk is probably low at oral doses of selegiline used in Parkinson disease but may be higher with higher doses or the transdermal form.
How serious is the interaction between Ondansetron and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity when ondansetron is given with selegiline. Consider a non-serotonergic antiemetic where feasible.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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