Drug interactions
Ondansetron + Selpercatinib
Severity: Moderate
Ondansetron and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, as can ondansetron. Combined use may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Ondansetron and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes and correct potassium, magnesium and calcium. Consider an alternative antiemetic if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Ondansetron with Selpercatinib?
MediHelp rates the interaction as moderate. Ondansetron and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, as can ondansetron. Combined use may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Ondansetron and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and correct potassium, magnesium and calcium. Consider an alternative antiemetic if QTc becomes prolonged.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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