Drug interactions
Ondansetron + Sotorasib
Severity: Minor
Ondansetron and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein inducer or modulator that may alter the exposure of P-gp substrates. The effect on ondansetron is likely modest and may reduce its antiemetic effect.
What this interaction means in plain words
Ondansetron and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may alter P-glycoprotein transport, though ondansetron is only a partial P-gp substrate.
What to do
No routine dose change is needed. Monitor antiemetic efficacy and add or switch agents if control of nausea is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Ondansetron with Sotorasib?
MediHelp rates the interaction as minor. Ondansetron and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a P-glycoprotein inducer or modulator that may alter the exposure of P-gp substrates. The effect on ondansetron is likely modest and may reduce its antiemetic effect.
How serious is the interaction between Ondansetron and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor antiemetic efficacy and add or switch agents if control of nausea is inadequate.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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