Drug interactions
Oritavancin + Tacrolimus
Severity: Minor
Oritavancin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oritavancin is a weak CYP3A4 inducer and may slightly reduce tacrolimus concentrations. The clinical effect is probably small but tacrolimus has a narrow therapeutic range.
What this interaction means in plain words
Oritavancin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oritavancin belongs to Anti Bacterial; Tacrolimus belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 increases tacrolimus clearance.
What to do
Check a tacrolimus trough level during and after oritavancin therapy and adjust the dose only if levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Oritavancin
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Cyclosporin + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Flecainide + Oritavancin Minor
Frequently asked questions
Can I take Oritavancin with Tacrolimus?
MediHelp rates the interaction as minor. Oritavancin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oritavancin is a weak CYP3A4 inducer and may slightly reduce tacrolimus concentrations. The clinical effect is probably small but tacrolimus has a narrow therapeutic range.
How serious is the interaction between Oritavancin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a tacrolimus trough level during and after oritavancin therapy and adjust the dose only if levels fall.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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