Drug interactions
Orlistat + Vitamin d
Severity: Moderate
Orlistat and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat blocks fat absorption and can reduce absorption of fat-soluble vitamins including vitamin D. Long-term use may lower vitamin D status.
What this interaction means in plain words
Orlistat and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Orlistat inhibits gastrointestinal lipases, reducing absorption of fat-soluble vitamin D.
What to do
Take vitamin D at least 2 hours before or after orlistat, such as at bedtime. Monitor vitamin D levels during long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Orlistat and Vitamin d, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vitamin d
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Orlistat with Vitamin d?
MediHelp rates the interaction as moderate. Orlistat and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat blocks fat absorption and can reduce absorption of fat-soluble vitamins including vitamin D. Long-term use may lower vitamin D status.
How serious is the interaction between Orlistat and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin D at least 2 hours before or after orlistat, such as at bedtime. Monitor vitamin D levels during long-term therapy.
What other medicines interact with Vitamin d?
MediHelp also lists interactions of Vitamin d with, for example, Aluminum hydroxide, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Vitamin d page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
