Drug interactions
Orphenadrin + Papaverine
Severity: Minor
Orphenadrin and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine can cause mild sedation and dizziness, and orphenadrine has central depressant effects. The additive effect is likely small, though some patients may notice more drowsiness.
What this interaction means in plain words
Orphenadrin and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Orphenadrin belongs to Musculoskeletal; Papaverine belongs to Cardiovascular.
Why it happens
Possible additive mild central nervous system depression.
What to do
No routine change is needed. Advise patients to watch for drowsiness before driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orphenadrin
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Orphenadrin with Papaverine?
MediHelp rates the interaction as minor. Orphenadrin and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine can cause mild sedation and dizziness, and orphenadrine has central depressant effects. The additive effect is likely small, though some patients may notice more drowsiness.
How serious is the interaction between Orphenadrin and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to watch for drowsiness before driving.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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