Drug interactions
Orphenadrin + Perphenazine
Severity: Moderate
Orphenadrin and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine causes sedation and some anticholinergic effects, and orphenadrine adds to both. Combined use may cause drowsiness, confusion, constipation and urinary retention.
What this interaction means in plain words
Orphenadrin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic toxicity, especially in older adults. Reduce doses if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Orphenadrin with Perphenazine?
MediHelp rates the interaction as moderate. Orphenadrin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine causes sedation and some anticholinergic effects, and orphenadrine adds to both. Combined use may cause drowsiness, confusion, constipation and urinary retention.
How serious is the interaction between Orphenadrin and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, especially in older adults. Reduce doses if symptoms develop.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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