Drug interactions
Orphenadrin + Succinylcholine
Severity: Minor
Orphenadrin and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-documented interaction exists between these drugs. Orphenadrine has weak anticholinergic and neuromuscular effects, but any change in succinylcholine blockade is theoretical and unpredictable.
What this interaction means in plain words
Orphenadrin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Orphenadrin belongs to Musculoskeletal; Succinylcholine belongs to Musculoskeletal.
Why it happens
Mechanism is not established; a theoretical effect on neuromuscular transmission is possible.
What to do
Monitor neuromuscular blockade with a nerve stimulator during anesthesia. No preemptive dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orphenadrin
Other interactions of Succinylcholine
Frequently asked questions
Can I take Orphenadrin with Succinylcholine?
MediHelp rates the interaction as minor. Orphenadrin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-documented interaction exists between these drugs. Orphenadrine has weak anticholinergic and neuromuscular effects, but any change in succinylcholine blockade is theoretical and unpredictable.
How serious is the interaction between Orphenadrin and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with a nerve stimulator during anesthesia. No preemptive dose change is needed.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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