Drug interactions
Orphenadrin + Temazepam
Severity: Moderate
Orphenadrin and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has central depressant and anticholinergic properties that add to the sedative effect of temazepam. The combination can cause more drowsiness, dizziness, confusion and impaired psychomotor performance, especially in older adults.
What this interaction means in plain words
Orphenadrin and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Temazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Use the lowest effective doses and warn patients about impaired driving and operating machinery. Monitor older or frail patients for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Orphenadrin with Temazepam?
MediHelp rates the interaction as moderate. Orphenadrin and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has central depressant and anticholinergic properties that add to the sedative effect of temazepam. The combination can cause more drowsiness, dizziness, confusion and impaired psychomotor performance, especially in older adults.
How serious is the interaction between Orphenadrin and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about impaired driving and operating machinery. Monitor older or frail patients for oversedation and falls.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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