Drug interactions
Orphenadrine + Propofol
Severity: Moderate
Orphenadrine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant with sedative properties, and it can add to the CNS depression caused by propofol. Greater drowsiness, confusion and hypotension may result.
What this interaction means in plain words
Orphenadrine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from central anticholinergic and antihistaminic effects plus propofol GABAergic activity.
What to do
Titrate propofol to effect with a possibly lower dose and monitor sedation level and vital signs, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Orphenadrine with Propofol?
MediHelp rates the interaction as moderate. Orphenadrine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant with sedative properties, and it can add to the CNS depression caused by propofol. Greater drowsiness, confusion and hypotension may result.
How serious is the interaction between Orphenadrine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with a possibly lower dose and monitor sedation level and vital signs, particularly in older patients.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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