Drug interactions
Osilodrostat + Primaquine
Severity: Moderate
Osilodrostat and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and primaquine also has a QT effect. Combined use may increase arrhythmia risk, especially if hypokalemia is present, which is common in Cushing syndrome.
What this interaction means in plain words
Osilodrostat and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Primaquine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain an ECG at baseline and monitor QTc, and correct potassium and magnesium before and during treatment. Reassess the combination if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Primaquine?
MediHelp rates the interaction as moderate. Osilodrostat and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and primaquine also has a QT effect. Combined use may increase arrhythmia risk, especially if hypokalemia is present, which is common in Cushing syndrome.
How serious is the interaction between Osilodrostat and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and monitor QTc, and correct potassium and magnesium before and during treatment. Reassess the combination if QTc rises significantly.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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