Drug interactions
Osilodrostat + Quetiapine
Severity: Major
Osilodrostat and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to the risk.
What this interaction means in plain words
Osilodrostat and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osilodrostat belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with osilodrostat-related hypokalemia as a further contributor.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor ECG and electrolytes periodically. Consider an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Quetiapine?
MediHelp rates the interaction as major. Osilodrostat and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to the risk.
How serious is the interaction between Osilodrostat and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting, then monitor ECG and electrolytes periodically. Consider an alternative if QTc becomes prolonged.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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