Drug interactions
Osilodrostat + Quinidine
Severity: Major
Osilodrostat and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combined use may raise the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, further increasing risk.
What this interaction means in plain words
Osilodrostat and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osilodrostat belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization, with hypokalemia as a potentiating factor.
What to do
Obtain a baseline ECG and monitor QTc after starting or adjusting therapy. Correct potassium and magnesium deficits, or choose an alternative to quinidine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Quinidine?
MediHelp rates the interaction as major. Osilodrostat and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so combined use may raise the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, further increasing risk.
How serious is the interaction between Osilodrostat and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc after starting or adjusting therapy. Correct potassium and magnesium deficits, or choose an alternative to quinidine.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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