Drug interactions
Osilodrostat + Rifampicin
Severity: Moderate
Osilodrostat and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong enzyme inducers like rifampicin may reduce osilodrostat exposure and weaken cortisol control in Cushing's disease. Symptoms and biochemical control can worsen.
What this interaction means in plain words
Osilodrostat and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and CYP2B6 increases osilodrostat metabolism.
What to do
Monitor cortisol levels and clinical symptoms and increase the osilodrostat dose if needed. Reduce the dose again when rifampicin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Osilodrostat
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Osilodrostat with Rifampicin?
MediHelp rates the interaction as moderate. Osilodrostat and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong enzyme inducers like rifampicin may reduce osilodrostat exposure and weaken cortisol control in Cushing's disease. Symptoms and biochemical control can worsen.
How serious is the interaction between Osilodrostat and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and clinical symptoms and increase the osilodrostat dose if needed. Reduce the dose again when rifampicin is stopped.
What other medicines interact with Osilodrostat?
MediHelp also lists interactions of Osilodrostat with, for example, Amiodarone, Amisulpride, Chlorpromazine. The full list is on the Osilodrostat page.
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