Drug interactions
Osilodrostat + Secobarbital
Severity: Moderate
Osilodrostat and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower osilodrostat exposure through enzyme induction, potentially reducing control of cortisol excess. The effect has been described mainly with strong CYP3A4 inducers.
What this interaction means in plain words
Osilodrostat and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction by secobarbital increases osilodrostat clearance.
What to do
Monitor cortisol levels and clinical signs of hypercortisolism, and increase the osilodrostat dose if control is lost. Reassess the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Secobarbital?
MediHelp rates the interaction as moderate. Osilodrostat and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower osilodrostat exposure through enzyme induction, potentially reducing control of cortisol excess. The effect has been described mainly with strong CYP3A4 inducers.
How serious is the interaction between Osilodrostat and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and clinical signs of hypercortisolism, and increase the osilodrostat dose if control is lost. Reassess the dose when the barbiturate is stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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