Drug interactions
Osilodrostat + Sertraline
Severity: Moderate
Osilodrostat and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with hypokalemia, bradycardia or heart disease.
What this interaction means in plain words
Osilodrostat and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac repolarisation effects.
What to do
Obtain a baseline ECG and repeat after initiation or dose changes. Correct potassium and magnesium, as osilodrostat can cause hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Sertraline?
MediHelp rates the interaction as moderate. Osilodrostat and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is higher with hypokalemia, bradycardia or heart disease.
How serious is the interaction between Osilodrostat and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after initiation or dose changes. Correct potassium and magnesium, as osilodrostat can cause hypokalemia.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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