Drug interactions
Osilodrostat + Valproic acid
Severity: Minor
Osilodrostat and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat has been shown to affect some CYP enzymes, but valproate depends only slightly on CYP2C19. A clinically important change in valproate exposure is not expected.
What this interaction means in plain words
Osilodrostat and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Osilodrostat belongs to Endocrine; Valproic acid belongs to Central Nervous System.
Why it happens
Possible modest effect on a minor CYP2C19 pathway of valproate; not well established.
What to do
No routine action is required. Check valproate levels if clinical response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Valproic acid?
MediHelp rates the interaction as minor. Osilodrostat and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Osilodrostat has been shown to affect some CYP enzymes, but valproate depends only slightly on CYP2C19. A clinically important change in valproate exposure is not expected.
How serious is the interaction between Osilodrostat and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. Check valproate levels if clinical response changes.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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