Drug interactions
Osimertinib + Propafenone
Severity: Moderate
Osimertinib and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and propafenone has proarrhythmic and conduction-slowing effects. Combined use raises the risk of QT prolongation and ventricular arrhythmia.
What this interaction means in plain words
Osimertinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Obtain baseline and periodic ECGs and correct potassium and magnesium. Stop or reconsider therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Propafenone?
MediHelp rates the interaction as moderate. Osimertinib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and propafenone has proarrhythmic and conduction-slowing effects. Combined use raises the risk of QT prolongation and ventricular arrhythmia.
How serious is the interaction between Osimertinib and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct potassium and magnesium. Stop or reconsider therapy if QTc becomes markedly prolonged.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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