Drug interactions
Osimertinib + Quetiapine
Severity: Moderate
Osimertinib and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use may raise the risk of ventricular arrhythmia. The risk is greater with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Osimertinib and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Perform periodic ECG and electrolyte monitoring and correct potassium and magnesium abnormalities. Stop or change therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Quetiapine?
MediHelp rates the interaction as moderate. Osimertinib and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so combined use may raise the risk of ventricular arrhythmia. The risk is greater with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Osimertinib and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring and correct potassium and magnesium abnormalities. Stop or change therapy if QTc becomes markedly prolonged.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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