Drug interactions
Osimertinib + Quinidine
Severity: Major
Osimertinib and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combining them increases the risk of serious ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Osimertinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osimertinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid the combination if possible. If necessary, monitor ECG and electrolytes periodically and stop osimertinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Quinidine?
MediHelp rates the interaction as major. Osimertinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so combining them increases the risk of serious ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Osimertinib and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor ECG and electrolytes periodically and stop osimertinib if QTc becomes markedly prolonged.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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