Drug interactions
Osimertinib + Regorafenib
Severity: Moderate
Osimertinib and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and increase osimertinib exposure. This could raise the risk of QT prolongation, interstitial lung disease and rash.
What this interaction means in plain words
Osimertinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibits BCRP efflux of osimertinib.
What to do
Monitor ECG and electrolytes, and watch for respiratory symptoms. Reduce or interrupt osimertinib if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Regorafenib?
MediHelp rates the interaction as moderate. Osimertinib and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and increase osimertinib exposure. This could raise the risk of QT prolongation, interstitial lung disease and rash.
How serious is the interaction between Osimertinib and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for respiratory symptoms. Reduce or interrupt osimertinib if toxicity develops.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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