Drug interactions
Ospemifene + Quinidine
Severity: Minor
Ospemifene and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a weak CYP3A4 inhibitor and may slightly increase ospemifene exposure. The clinical effect is likely small.
What this interaction means in plain words
Ospemifene and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ospemifene belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4 and possibly other pathways involved in ospemifene metabolism, modestly raising its levels.
What to do
No dose adjustment is usually needed. Watch for ospemifene adverse effects such as hot flushes or thromboembolic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Ospemifene with Quinidine?
MediHelp rates the interaction as minor. Ospemifene and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine is a weak CYP3A4 inhibitor and may slightly increase ospemifene exposure. The clinical effect is likely small.
How serious is the interaction between Ospemifene and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for ospemifene adverse effects such as hot flushes or thromboembolic symptoms.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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