Drug interactions
Oteseconazole + Topotecan
Severity: Moderate
Oteseconazole and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP and has a very long half-life, so the inhibitory effect persists for months. Topotecan exposure may increase, raising the risk of myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Oteseconazole and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oteseconazole belongs to Anti Fungals; Topotecan belongs to Oncology.
Why it happens
BCRP inhibition by oteseconazole reduces topotecan efflux and elimination.
What to do
Monitor blood counts closely and consider a lower starting dose of topotecan; remember the inhibition may persist long after oteseconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Oteseconazole with Topotecan?
MediHelp rates the interaction as moderate. Oteseconazole and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and has a very long half-life, so the inhibitory effect persists for months. Topotecan exposure may increase, raising the risk of myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Oteseconazole and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider a lower starting dose of topotecan; remember the inhibition may persist long after oteseconazole is stopped.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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