Drug interactions
Oxaliplatin + Quinidine
Severity: Major
Oxaliplatin and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and torsades de pointes. Combined with quinidine, the arrhythmic risk increases, especially when chemotherapy causes vomiting, diarrhea or electrolyte loss.
What this interaction means in plain words
Oxaliplatin and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, worsened by oxaliplatin-related hypokalemia and hypomagnesemia.
What to do
Check baseline and periodic ECG and electrolytes, correcting potassium and magnesium. Use an alternative antiarrhythmic if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Quinidine?
MediHelp rates the interaction as major. Oxaliplatin and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaliplatin has been associated with QT prolongation and torsades de pointes. Combined with quinidine, the arrhythmic risk increases, especially when chemotherapy causes vomiting, diarrhea or electrolyte loss.
How serious is the interaction between Oxaliplatin and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECG and electrolytes, correcting potassium and magnesium. Use an alternative antiarrhythmic if possible.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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