Drug interactions
Oxaliplatin + Tetrabenazine
Severity: Major
Oxaliplatin and Tetrabenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine prolongs the QT interval in a dose-related way, and oxaliplatin has also been associated with QT prolongation. Combined use may add to the risk of ventricular arrhythmias, especially with electrolyte disturbances.
What this interaction means in plain words
Oxaliplatin and Tetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and correct potassium and magnesium before and during co-therapy. Use the lowest effective tetrabenazine dose, or choose an alternative if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Tetrabenazine?
MediHelp rates the interaction as major. Oxaliplatin and Tetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tetrabenazine prolongs the QT interval in a dose-related way, and oxaliplatin has also been associated with QT prolongation. Combined use may add to the risk of ventricular arrhythmias, especially with electrolyte disturbances.
How serious is the interaction between Oxaliplatin and Tetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during co-therapy. Use the lowest effective tetrabenazine dose, or choose an alternative if QTc rises significantly.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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