Drug interactions
Oxaliplatin + Thioridazine
Severity: Contraindicated
Oxaliplatin and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and torsades de pointes, and thioridazine strongly prolongs QTc. Used together the risk of life-threatening ventricular arrhythmia increases. Electrolyte disturbances from chemotherapy such as vomiting-related hypokalemia add to the risk.
What this interaction means in plain words
Oxaliplatin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Oxaliplatin belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Additive delayed cardiac repolarization and QT prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antipsychotic or antiemetic regimen. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Thioridazine?
MediHelp rates the interaction as contraindicated. Oxaliplatin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxaliplatin has been associated with QT prolongation and torsades de pointes, and thioridazine strongly prolongs QTc. Used together the risk of life-threatening ventricular arrhythmia increases. Electrolyte disturbances from chemotherapy such as vomiting-related hypokalemia add to the risk.
How serious is the interaction between Oxaliplatin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antipsychotic or antiemetic regimen. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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