Drug interactions
Oxaliplatin + Topotecan
Severity: Major
Oxaliplatin and Topotecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Platinum agents combined with topotecan cause greater neutropenia and thrombocytopenia than either alone, with worse toxicity when the platinum is given first. This can force dose reductions or treatment delays.
What this interaction means in plain words
Oxaliplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Additive myelosuppression with sequence-dependent enhancement of hematologic toxicity.
What to do
Monitor blood counts closely and use reduced doses of topotecan. Consider giving the platinum after topotecan where the regimen permits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Oxaliplatin with Topotecan?
MediHelp rates the interaction as major. Oxaliplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Platinum agents combined with topotecan cause greater neutropenia and thrombocytopenia than either alone, with worse toxicity when the platinum is given first. This can force dose reductions or treatment delays.
How serious is the interaction between Oxaliplatin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and use reduced doses of topotecan. Consider giving the platinum after topotecan where the regimen permits.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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