Drug interactions
Oxaliplatin + Trilaciclib
Severity: Moderate
Oxaliplatin and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits the renal transporters OCT2, MATE1 and MATE2-K, which are involved in the renal handling of platinum compounds. This may change oxaliplatin exposure in the kidney and blood and potentially alter its toxicity.
What this interaction means in plain words
Oxaliplatin and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of OCT2/MATE1/MATE2-K may alter the renal transport and clearance of oxaliplatin.
What to do
Monitor renal function and signs of oxaliplatin toxicity such as neuropathy and myelosuppression. Consider avoiding trilaciclib with oxaliplatin unless the benefit is clear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Trilaciclib
Frequently asked questions
Can I take Oxaliplatin with Trilaciclib?
MediHelp rates the interaction as moderate. Oxaliplatin and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits the renal transporters OCT2, MATE1 and MATE2-K, which are involved in the renal handling of platinum compounds. This may change oxaliplatin exposure in the kidney and blood and potentially alter its toxicity.
How serious is the interaction between Oxaliplatin and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and signs of oxaliplatin toxicity such as neuropathy and myelosuppression. Consider avoiding trilaciclib with oxaliplatin unless the benefit is clear.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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