Drug interactions
Oxaliplatin + Vancomycin
Severity: Moderate
Oxaliplatin and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin is less nephrotoxic than cisplatin but can still impair renal function. Vancomycin adds nephrotoxic risk, and both drugs have some potential to affect hearing.
What this interaction means in plain words
Oxaliplatin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Vancomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and possible ototoxicity.
What to do
Monitor renal function before each oxaliplatin cycle and during vancomycin therapy, using vancomycin level-guided dosing. Report new hearing changes or tinnitus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Vancomycin?
MediHelp rates the interaction as moderate. Oxaliplatin and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin is less nephrotoxic than cisplatin but can still impair renal function. Vancomycin adds nephrotoxic risk, and both drugs have some potential to affect hearing.
How serious is the interaction between Oxaliplatin and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function before each oxaliplatin cycle and during vancomycin therapy, using vancomycin level-guided dosing. Report new hearing changes or tinnitus.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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