Drug interactions
Oxaliplatin + Zidovudine
Severity: Moderate
Oxaliplatin and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin can cause neutropenia, thrombocytopenia and anemia, and zidovudine adds marrow toxicity. The combination may increase cytopenias and complicate chemotherapy delivery.
What this interaction means in plain words
Oxaliplatin and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppression (pharmacodynamic synergism).
What to do
Monitor complete blood counts before each chemotherapy cycle. Consider using a non-myelosuppressive antiretroviral during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Zidovudine?
MediHelp rates the interaction as moderate. Oxaliplatin and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin can cause neutropenia, thrombocytopenia and anemia, and zidovudine adds marrow toxicity. The combination may increase cytopenias and complicate chemotherapy delivery.
How serious is the interaction between Oxaliplatin and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each chemotherapy cycle. Consider using a non-myelosuppressive antiretroviral during chemotherapy.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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