Drug interactions
Oxaprozin + Pegaspargase
Severity: Moderate
Oxaprozin and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can reduce coagulation factors and cause thrombocytopenia or coagulopathy, while oxaprozin impairs platelet function and can injure the gastric mucosa. Together, bleeding risk may be increased.
What this interaction means in plain words
Oxaprozin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive effects on hemostasis: asparaginase-related coagulation protein depletion plus NSAID platelet inhibition.
What to do
Avoid NSAIDs where possible around pegaspargase therapy; if used, monitor platelet counts, coagulation tests and signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Oxaprozin with Pegaspargase?
MediHelp rates the interaction as moderate. Oxaprozin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can reduce coagulation factors and cause thrombocytopenia or coagulopathy, while oxaprozin impairs platelet function and can injure the gastric mucosa. Together, bleeding risk may be increased.
How serious is the interaction between Oxaprozin and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible around pegaspargase therapy; if used, monitor platelet counts, coagulation tests and signs of bleeding.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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