Drug interactions
Oxaprozin + Piroxicam
Severity: Major
Oxaprozin and Piroxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs gives no added efficacy and increases the risk of gastrointestinal bleeding, ulceration, renal injury and cardiovascular events.
What this interaction means in plain words
Oxaprozin and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaprozin belongs to Musculoskeletal; Piroxicam belongs to Musculoskeletal.
Why it happens
Duplicate cyclooxygenase inhibition produces additive gastric mucosal damage, platelet inhibition and renal prostaglandin suppression.
What to do
Avoid using two systemic NSAIDs together; use a single agent at the lowest effective dose. Add paracetamol if more analgesia is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Oxaprozin with Piroxicam?
MediHelp rates the interaction as major. Oxaprozin and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs gives no added efficacy and increases the risk of gastrointestinal bleeding, ulceration, renal injury and cardiovascular events.
How serious is the interaction between Oxaprozin and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two systemic NSAIDs together; use a single agent at the lowest effective dose. Add paracetamol if more analgesia is needed.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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