Drug interactions
Oxaprozin + Tacrolimus
Severity: Major
Oxaprozin and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can impair kidney function, and using them together raises the risk of acute kidney injury and a rise in serum creatinine. Tacrolimus constricts the afferent arteriole and NSAIDs remove the compensatory prostaglandin-mediated vasodilation.
What this interaction means in plain words
Oxaprozin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaprozin belongs to Musculoskeletal; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity through tacrolimus-induced afferent vasoconstriction combined with NSAID inhibition of renal vasodilatory prostaglandins.
What to do
Avoid the NSAID where possible and use paracetamol or another alternative. If unavoidable, use the lowest dose for the shortest time and monitor serum creatinine, potassium and tacrolimus trough levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Oxaprozin with Tacrolimus?
MediHelp rates the interaction as major. Oxaprozin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can impair kidney function, and using them together raises the risk of acute kidney injury and a rise in serum creatinine. Tacrolimus constricts the afferent arteriole and NSAIDs remove the compensatory prostaglandin-mediated vasodilation.
How serious is the interaction between Oxaprozin and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID where possible and use paracetamol or another alternative. If unavoidable, use the lowest dose for the shortest time and monitor serum creatinine, potassium and tacrolimus trough levels.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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