Drug interactions
Oxaprozin + Torsemide
Severity: Moderate
Oxaprozin and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and may cause fluid retention. In susceptible patients the combination can also contribute to acute kidney injury.
What this interaction means in plain words
Oxaprozin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Torsemide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, antagonizing loop diuretic effect.
What to do
Monitor weight, blood pressure, edema and renal function, and increase the torsemide dose if the diuretic response is reduced. Avoid in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Torsemide
Frequently asked questions
Can I take Oxaprozin with Torsemide?
MediHelp rates the interaction as moderate. Oxaprozin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and may cause fluid retention. In susceptible patients the combination can also contribute to acute kidney injury.
How serious is the interaction between Oxaprozin and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, blood pressure, edema and renal function, and increase the torsemide dose if the diuretic response is reduced. Avoid in volume-depleted patients.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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