Drug interactions
Oxazepam + Pregabalin
Severity: Major
Oxazepam and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and oxazepam both depress the CNS, and combined use increases the risk of marked sedation, impaired cognition and respiratory depression. Risk is highest in older adults, those with respiratory disease, and with higher doses.
What this interaction means in plain words
Oxazepam and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxazepam belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation and alpha-2-delta calcium channel modulation.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression; consider dose reduction of one agent if drowsiness occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Oxazepam with Pregabalin?
MediHelp rates the interaction as major. Oxazepam and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin and oxazepam both depress the CNS, and combined use increases the risk of marked sedation, impaired cognition and respiratory depression. Risk is highest in older adults, those with respiratory disease, and with higher doses.
How serious is the interaction between Oxazepam and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression; consider dose reduction of one agent if drowsiness occurs.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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