Drug interactions
Oxazepam + Risperidone
Severity: Moderate
Oxazepam and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination can cause additive sedation, dizziness and orthostatic hypotension. This increases the risk of falls and impaired alertness, particularly in older adults.
What this interaction means in plain words
Oxazepam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and risperidone antagonism of alpha-1 adrenergic and histamine receptors.
What to do
Monitor for sedation and orthostatic hypotension, and start with low doses. Counsel patients against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Oxazepam with Risperidone?
MediHelp rates the interaction as moderate. Oxazepam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination can cause additive sedation, dizziness and orthostatic hypotension. This increases the risk of falls and impaired alertness, particularly in older adults.
How serious is the interaction between Oxazepam and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, and start with low doses. Counsel patients against driving until the response is known.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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