Drug interactions
Oxazepam + Trazodone
Severity: Moderate
Oxazepam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and together they can cause additive drowsiness, dizziness and orthostatic hypotension. Falls and impaired performance are the main concerns, especially in older patients.
What this interaction means in plain words
Oxazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxazepam belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and trazodone antagonism of histamine H1, 5-HT2A and alpha-1 receptors.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Advise avoiding alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Oxazepam with Trazodone?
MediHelp rates the interaction as moderate. Oxazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and together they can cause additive drowsiness, dizziness and orthostatic hypotension. Falls and impaired performance are the main concerns, especially in older patients.
How serious is the interaction between Oxazepam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Advise avoiding alcohol and driving until the response is known.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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