Drug interactions
Oxcarbazepine + Oxycodone
Severity: Moderate
Oxcarbazepine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak to moderate CYP3A4 inducer and may lower oxycodone concentrations, potentially reducing analgesia. Oxcarbazepine can also cause drowsiness that adds to opioid sedation.
What this interaction means in plain words
Oxcarbazepine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by oxcarbazepine increases oxycodone metabolism; additive CNS depression.
What to do
Monitor pain control and titrate oxycodone as needed. Watch for sedation and reassess the dose if oxcarbazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Oxycodone?
MediHelp rates the interaction as moderate. Oxcarbazepine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak to moderate CYP3A4 inducer and may lower oxycodone concentrations, potentially reducing analgesia. Oxcarbazepine can also cause drowsiness that adds to opioid sedation.
How serious is the interaction between Oxcarbazepine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate oxycodone as needed. Watch for sedation and reassess the dose if oxcarbazepine is stopped.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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